Written by Nathan Wellington
Brain-Derived Neurotrophic Factor
Gene/Protein of the Month
Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin — a protein critical for neuronal growth, survival, and synaptic plasticity. Structurally, BDNF is a 27 kDa protein composed of 247 amino acids, folded into a characteristic “cysteine knot” structure that stabilises its activity.
The BDNF gene, located on chromosome 11p14.1, spans more than 70 kilobases and includes multiple promoters, allowing tissue-specific and activity-dependent regulation. One well-studied variation, the Val66Met polymorphism, alters the secretion of BDNF, affecting stress resilience and therapeutic response.
Reduced BDNF expression and signalling are consistently observed in depression, PTSD, bipolar disorder, and schizophrenia, underscoring its cross-diagnostic importance. Because of its central role in synaptic plasticity and stress adaptation, BDNF is considered a key biomarker and therapeutic target in precision psychiatry.
Written by Dr Megan Dutton
As a clinician and researcher in the field of neuroscience and mental health, I’ve seen how a precise, multidisciplinary approach to ADHD can transform lives. At Brain and Mind Hub, we’ve developed a neuroscience-informed model that integrates clinical accuracy with holistic care—ensuring individuals with ADHD receive not only a correct diagnosis but also the tools to thrive.
